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ارجو منكم افادتي عن هذه المواد لانني بامس الحاجة لمعرفة معلومات كافية و وافية عنها

استخداماتها و تاثيراتها الدوائية و هل تقبل المزج مع مادة اخرى و كيف تعطى و ما هي الجرعات المناسبة

المواد هي :

difloxacin hcl , kitasamycin tartrate , norfloxacin hcl , thiam phenicol

هاحاول ارد علي حضرتك حالا ان شاء الله
بس معظم الحاجات دياسماء ادوية بشريه ومنتجات شركات كبيره
انتظر الدر بعد قليل

Difloxacin HCL

Brand
Dicural

Availability

Tablets: 11.4 mg, 45.4 mg and 136 mg
Pharmacology
This is a newer 4-Fluoroquinolone and like that of other fluoroquinolones is a broad-spectrum, bactericidal, antibiotic. It is concentration dependent and similar to enrofloxacin.

Difloxacin has activity against some Gram-positive aerobes and a wide range of Gram-negative bacilli and cocci, which include klebsiella, pseudomonas, salmonella, and other organisms such as mycoplasma, staphylococci, and chlamydia. The mechanism of action is to inhibit bacterial DNA-gyrase, prevent DNA synthesis, and disrupt bacterial cell duplication.

Difloxacin is documented as having a longer elimination half-life than other fluoroquinolones, staying in the body longer. This allows for once a day dosing, however, it’s efficacy appears to be the same as enrofloxacin.

The safety of this drug for use in pregnant and nursing animals has not been determined.

The quinolone class of drugs have been shown to produce erosion of cartilage in weight bearing joints and other signs of arthropathy in immature animals of various species.

The use of fluoroquinolones has not been recommended for initial treatment in pregnant and nursing does, or rats under 4 months due to the risks of cartilage abnormalities (Egerbacher et al., 2000), however, in cases where other antibiotics are not helping, or if the infection is deemed severe, the benefit of using fluoroquinolones (alone or in combination with other compatible antimicrobials) may in
fact outweigh the risks.

Indications

Useful in urinary tract infections, soft tissue injury, and mycoplasma.

Drug Interactions or Contraindications

Antacids containing Magnesium, Calcium, and Aluminum will prevent absorption.

Theophylline blood levels may be increased when used with difloxacin.

Probenecid blocks tubular secretion of difloxacin and may cause an increase in its blood level and half life.

Synergism can occur when aminoglycosides, cephalosporins, and extended-spectrum penicillins are used with fluorinated quinolones such as difloxacin.

Adverse Reactions

CNS: restlessness, may lower seizure threshold (increasing likelihood of seizure activity)

GI: decreased appetite, diarrhea

GU: crystaluria

Skin: can cause tissue damage when given IM or SQ

Other: itching
Dosage Recommendations
4.5 mg/lb , PO , BID 3

Note: see warning for young, pregnant or nursing rats in Pharmacology section above.

Considerations

* Store tablets in tight moist free container.
* Be sure to keep animals well hydrated in order to prevent crystalluria (formation of crystals in urine).
* Reconstituted suspension from tablets should be kept refrigerated and has a 14 day expiration time.
* Difloxacin can be used simultaneously with doxycycline in the treatment of Mycoplasma.

Also, in treating suspected polymicrobial infections, where a broader coverage may be needed, synergistic or combination drugs may be used. The following drugs may be seen used simultaneously with ciprofloxacin: aminoglycosides (e.g., amikacin or gentamicin), or aminopenicillins (e.g., amoxicillin or ampicillin), or third generation cephalosporins, or clindamycin, or metronidazole. 1
* Please note that it is imperative to discuss the changing, or adding of any medications during your rat’s treatment with your veterinarian, to prevent future resistance of microbes to the drugs prescribed.

Reference

* Egerbacher, M., Seiberl, G., Wolfesberger, B., & Walter, I. (2000). Ciprofloxacin causes cytoskeletal changes and detachment of human and rat chondrocytes in vitro. Arch Toxicol, 73(10-11), 557-63. Retrieved December 20, 2008, from the PubMed database.

جزاك الله خيرا

هل من معلومات اخرى ؟؟؟

شكرا جزيلا لك يا اخي

بالنسبة لل Kitasamycin_Tartrate_

ده غالبا موجود في صورة بودره powder

وبيضاف اليالعلائف ك مضاد حيوي واضافات علائق feed additives

وهذا تركيبة

والكلام ع النت مش كتير عن الكاتامايسين ترترات

الا شوية معلومات كده

* Brand Name: Junyu
* Function: kill bacterial
* Type: Drug
* Place of Origin: Hebei China (Mainland)
* Dosage Form: Powder
* Model Number: 100g/bag
* Component: Kitasamycin Tartrate

Kitasamycin Tartrate Soluble Powder
Component: Kitasamycin Tartrate
Indications:
Antibiotic

Kitasamycin Tartrate Soluble Powder

Component: Kitasamycin Tartrate

Indications:

Antibiotic drug for Gram-positive bacteria, mycoplasma caused infectious diseases such as staphylococcus diseases, streptococcus diseases and mycoplasma diseases and so on.

Usage and Dosage:

Mixed drink: Poultry per 200kg water mixed the drug 100g and continue for 3-5 days.

Oral administration: Pigs: per 1kg body weight uses the drug 0.05g, continue for 3-5 days

Specification:100g/bag

وال

Norofloxacin hcl

ده برشام او كابسولات

افيدوني جزاكم الله خيرا Norflo

Generic name: Norfloxacin Tablets (nor-FLOX-a-sin)
Brand name: Noroxin

Description
Norfloxacin is a synthetic, broad-spectrum antibacterial agent for oral administration. It is a fluoroquinolone antibiotic, which works to kill sensitive bacteria.

Uses To treat certain infections caused by bacteria, like prostate, urinary tract infections and gonorrhea

How to take?
It comes as a tablet to take by mouth. Should be taken every 12 hours for 7-28 days, twice a day. For gonorrhea, a single dose is taken. Take norfloxacin exactly as directed by your doctor.

Safety tips
Before taking norfloxacin, follow the following guidelines:

* Tell your doctor and pharmacist if you are allergic to any type of drugs.
* Tell your doctor what prescription and nonprescription medications you are taking, especially other antibiotics.
* Do not take with antacids , chewable/buffered tablets or oral solution, iron or zinc supplements, or vitamins that contain iron or zinc. Take these medicines 2 hours before or after norfloxacin.
* Tell your doctor if you have kidney or liver disease, colitis, stomach problems, epilepsy, vision problems, heart disease, or history of stroke.
* Tell your doctor if you are pregnant or are breast-feeding or plan to become pregnant.
* If you are having surgery, tell the doctor that you are taking norfloxacin.
* Take Norfloxacin with a full glass of water.
* Drinking extra fluids while taking Norfloxacin is very essential.
* Continue taking Norfloxacin for the full course of treatment to clear up your infection completely.
* If you miss a dose , take it as soon as possible. Do not take 2 doses at once.

Side effects
All medicines have their side effects, which might affect people with minor or major or no side effects. Consuming norfloxacin might cause

* Dizziness
* Headache
* Diarrhea
* Nausea
* Vomiting
* Dark urine
* Unusual fatigue

* Loss of appetite
* Stomach upset or cramps
* Severe allergic reactions
* Trouble sleeping
* Vaginal yeast infection
* Yellowing of the skin or eyes etc.
* Vision changes

الله يجزيك الخير يا اخي و الله تقلت عليك اليوم

و بالنسبة للمادة الاخيرة

هل من معلومات

و ممكن تتكرم علي و تعطيني عنواين خاصة بمثل هذه الانواع من البحوث

جزاك الله خيرا

و أما عن ال Thiamphenicol

ف ده الكلام عنه كتير جدا ع النت لكن هاجيبلك الحاجات الطبيه والاستخدامات فقط

ومن الافضل اجيبلك اللينكات بتاعته تشوفها بنفسك

http://www.answers.com/topic/thiamphenicol

http://potency.berkeley.edu/chempages/THIAMPHENICOL.html

وده كتاب بي دي اف pdf عن ال ماده حمله من هنا

http://www.ncbi.nlm.nih.gov/pubmed/12583545

الله يجزيك الخير يا اخي و الله انا تقيل دم

جزاك الله عني كل خير و جعلها في ميزان حسناتك

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